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Location, location, location: B-cell differentiation in the gut lamina propria.

Authors
Type
Published Article
Journal
Mucosal Immunology
1935-3456
Publisher
Nature Publishing Group
Publication Date
Volume
1
Issue
1
Pages
8–10
Identifiers
DOI: 10.1038/mi.2007.8
PMID: 19079155
Source
Medline
License
Unknown

Abstract

The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.

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