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Localization and quantification of mRNA for matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in human benign and malignant prostatic tissue.

Authors
Type
Published Article
Journal
The Prostate
Publication Date
Volume
42
Issue
1
Pages
18–25
Identifiers
PMID: 10579795
Source
Medline
License
Unknown

Abstract

The results suggest a close association between MMP-2/TIMP-2 expression and local tumor invasion, with a disruption in expression of the two genes leading to disease progression. Future studies should focus on the activity of these enzymes and on the ratio of enzyme/inhibitor expression, which may become a useful prognostic marker in prostate cancer.

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