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Localization of the C3-Like ADP-Ribosyltransferase from Staphylococcus aureus during Bacterial Invasion of Mammalian Cells

Authors
  • Gabriella Molinari
  • Manfred Rohde
  • Christian Wilde
  • Ingo Just
  • Klaus Aktories
  • Gursharan S. Chhatwal
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2006
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The C3stau2 exoenzyme from Staphylococcus aureus is a C3-like ADP-ribosyltransferase which possesses no specific receptor-binding domain or translocation unit required for entry in target cells where its substrate is located. Here we show that C3stau2 can reach its target after invasion of staphylococci in eukaryotic cells without needing translocation.

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