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Localization of glutamate receptors at a complex synapse. The mammalian photoreceptor synapse.

Authors
  • Brandstätter, J H
  • Hack, I
Type
Published Article
Journal
Cell and tissue research
Publication Date
Jan 01, 2001
Volume
303
Issue
1
Pages
1–14
Identifiers
PMID: 11235997
Source
Medline
License
Unknown

Abstract

A key feature of signal processing in the mammalian retina is parallel processing, where the segregation of visual information, e.g., brightness, darkness, and color, starts at the first synapse in the retina, the photoreceptor synapse. These various aspects are transmitted in parallel from the input neurons of the retina, the photoreceptor cells, through the interconnecting bipolar cells, to the output neurons, the ganglion cells. The photoreceptors and bipolar cells release a single excitatory neurotransmitter, glutamate, at their synapses. This parsimony is contrasted by the expression of a plethora of glutamate receptors, receptor subunits, and isoforms. The detailed knowledge of the synaptic distribution of glutamate receptors thus is of major importance in understanding the mechanisms of retinal signal processing. This review intends to highlight recent studies on the distribution of glutamate receptors at the photoreceptor synapses of the mammalian retina.

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