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[Local use of aprotinin in neurosurgical operations for the prevention of hyperfibrinolytic hemorrhage].

Authors
  • Giromini, D
  • Tzonos, T
Type
Published Article
Journal
Fortschritte der Medizin
Publication Date
Aug 06, 1981
Volume
99
Issue
29
Pages
1153–1156
Identifiers
PMID: 6167502
Source
Medline
License
Unknown

Abstract

The local use of a commercial solution of the proteinase inhibitor aprotinin (Trasylol) prevents a premature fibrinolysis which may lead to post-operative hyperfibrinolytic bleeding. Among 1.236 neurosurgical patients in whom aprotinin was routinely locally applied there were 8 cases of post-operative bleeding (0,6%). In 7 of these cases an impaired coagulation had been previously found or was found during surgery. The intra-operative use of Trasylol appears to be suited to reduce the rate of post-operative haemorrhagic complications in neurosurgery.

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