The local use of a commercial solution of the proteinase inhibitor aprotinin (Trasylol) prevents a premature fibrinolysis which may lead to post-operative hyperfibrinolytic bleeding. Among 1.236 neurosurgical patients in whom aprotinin was routinely locally applied there were 8 cases of post-operative bleeding (0,6%). In 7 of these cases an impaired coagulation had been previously found or was found during surgery. The intra-operative use of Trasylol appears to be suited to reduce the rate of post-operative haemorrhagic complications in neurosurgery.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 07/01/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6167502