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Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017

Authors
  • Walter, Katharine S.
  • Tatara, Mariana Bento
  • Esther da Silva, Kesia
  • Moreira, Flora Martinez Figueira
  • dos Santos, Paulo Cesar Pereira
  • de Melo Ferrari, Dândrea Driely
  • Cunha, Eunice Atsuko
  • Andrews, Jason R.
  • Croda, Julio
Type
Published Article
Journal
Emerging Infectious Diseases
Publisher
Centers For Disease Control and Prevention
Publication Date
Mar 01, 2021
Volume
27
Issue
3
Pages
905–914
Identifiers
DOI: 10.3201/eid2703.203839
PMID: 33622493
PMCID: PMC7920644
Source
PubMed Central
Keywords
Disciplines
  • Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2
License
Unknown

Abstract

International migrants are at heightened risk for tuberculosis (TB) disease. Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated the contributions of migration, local transmission, or prisons in driving incident TB at international borders. We conducted prospective population-based genomic surveillance in 3 cities along Brazil’s central western border from 2014–2017. Although most isolates (89/132; 67%) fell within genomic transmission clusters, genetically unique isolates disproportionately occurred among participants with recent international travel (17/42; 40.5%), suggesting that both local transmission and migration contribute to incident TB. Isolates from 40 participants with and 76 without an incarceration history clustered together throughout a maximum-likelihood phylogeny, indicating the close interrelatedness of prison and community epidemics. Our findings highlight the need for ongoing surveillance to control continued introductions of TB and reduce the disproportionate burden of TB in prisons at Brazil’s international borders.

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