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Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract.

Authors
  • Hamidi Asl, K
  • Liepnieks, J J
  • Bihrle, R
  • Benson, M D
Type
Published Article
Journal
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
Publication Date
Mar 01, 1998
Volume
5
Issue
1
Pages
49–54
Identifiers
PMID: 9547006
Source
Medline
License
Unknown

Abstract

An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for lambda VI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to lambda VI Positive staining of subepithelial plasma cells with lambda VI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.

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