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Local infusion of heparin reduces anastomotic neointimal hyperplasia in aortoiliac expanded polytetrafluoroethylene bypass grafts in baboons.

Authors
  • Chen, C
  • Lumsden, A B
  • Hanson, S R
Type
Published Article
Journal
Journal of Vascular Surgery
Publisher
Elsevier
Publication Date
Feb 01, 2000
Volume
31
Issue
2
Pages
354–363
Identifiers
PMID: 10664503
Source
Medline
License
Unknown

Abstract

These results show that local infusion of heparin significantly reduces distal anastomotic neointimal hyperplasia and cell proliferation without measurable systemic anticoagulation or other side effects. Thus, this approach may represent an attractive strategy for prolonging ePTFE bypass graft patency.

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