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Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Authors
  • Wiest, C.1, 2
  • Tinkhauser, G.3
  • Pogosyan, A.1, 2
  • Bange, M.4
  • Muthuraman, M.4
  • Groppa, S.4
  • Baig, F.1, 2, 5
  • Mostofi, A.5
  • Pereira, E.A.5
  • Tan, H.1, 2
  • Brown, P.1, 2
  • Torrecillos, F.1, 2
  • 1 Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK
  • 2 Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
  • 3 Department of Neurology, Bern University Hospital, Bern, Switzerland
  • 4 Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Mainz University Hospital, Mainz, Germany
  • 5 Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK
Type
Published Article
Journal
Neurobiology of Disease
Publisher
Elsevier
Publication Date
Sep 01, 2020
Volume
143
Identifiers
DOI: 10.1016/j.nbd.2020.105019
PMID: 32681881
PMCID: PMC7115855
Source
PubMed Central
Keywords
License
Unknown

Abstract

• ERNA frequency and amplitude reach a steady state after ~70 s stimulation. • Beta activity is suppressed within 0.5 s by stimulation and then remains stable. • Different response dynamics provide different insights into stimulation effects. • Different response dynamics may impact how signals may be used in adaptive DBS.

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