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Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats.

Authors
  • Ayukawa, Yasunori1
  • Yasukawa, Eisuke
  • Moriyama, Yasuko
  • Ogino, Yoichiro
  • Wada, Hiroko
  • Atsuta, Ikiru
  • Koyano, Kiyoshi
  • 1 Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. [email protected] , (Japan)
Type
Published Article
Journal
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Publication Date
March 2009
Volume
107
Issue
3
Pages
336–342
Identifiers
DOI: 10.1016/j.tripleo.2008.07.013
PMID: 18801677
Source
Medline
License
Unknown

Abstract

New bone area increased under the influence of simvastatin; however, the effect did not continue when the administration was terminated. Osteoclast suppression may be the consequence of RANKL depression.

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