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LncRNAs AK058003 and MVIH Overexpression in the Blood Samples of Iranian Breast Cancer Patients

Authors
  • Akhavan Attar, Fatemeh1
  • Oloomi, Mana2
  • Irani, Shiva1
  • Azizi, Masoumeh3
  • Geranpayeh, Loabat4
  • 1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;
  • 2 Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran;
  • 3 Department of Molecular Medicine, Biotechnology Research Center; Pasteur Institute of Iran, Tehran, Iran;
  • 4 Department of 4th Surgery, Sina Hospital, Tehran, Iran
Type
Published Article
Journal
Iranian Biomedical Journal
Publisher
Pasteur Institute of Iran
Publication Date
Nov 04, 2020
Volume
25
Issue
2
Pages
93–98
Identifiers
DOI: 10.29252/ibj.25.2.93
PMID: 33462225
PMCID: PMC7921519
Source
PubMed Central
Keywords
Disciplines
  • Full Length
License
Green

Abstract

Background: LncRNAs are considered as novel biological regulators and potential cancer biomarkers. LncRNAs MVIH and AK058003 are associated with microvascular invasion in HCC. In BC, upregulated MVIH and AK058003 expression levels have been shown to promote cell proliferation, though LncRNA-AK058003 acts as a tumor suppressor in HCC. Methods: Blood samples were collected from 30 healthy women and 30 female BC patients. RNA was extracted from the blood of both groups, and cDNA was then synthesized. Real-time PCR was used to measure the expression level of LncRNA-AK058003 and MVIH. Results: The expression level of two LncRNAs in the blood samples of BC patients increased significantly compared with healthy individuals. The levels of AK058003 and MVIH were not associated with lymph node metastasis ( p = 0.402 and p = 0.39), tumor size ( p = 0.76 and p = 0.461), and TNM stage ( p = 0.574 and p = 0.711), respectively. Conclusion : As per our findings, LncRNA-AK058003 could serve as a suitable indicator for low stage of BC. In addition, the increased level of LncRNA-MVIH could be considered as a biomarker for BC, which needs more evaluation in the future.

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