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LncRNA: A Potential Research Direction in Intestinal Barrier Function.

Authors
  • Jiang, Zhi-Feng1
  • Zhang, Lin2
  • 1 Center of Emergency and Intensive Care Unit, Jinshan Hospital of Fudan University, Medical Research Center for Chemical Injury of Fudan University, No. 1508 Longhang Road, Shanghai, 201508, China. , (China)
  • 2 Center of Emergency and Intensive Care Unit, Jinshan Hospital of Fudan University, Medical Research Center for Chemical Injury of Fudan University, No. 1508 Longhang Road, Shanghai, 201508, China. [email protected] , (China)
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
May 01, 2021
Volume
66
Issue
5
Pages
1400–1408
Identifiers
DOI: 10.1007/s10620-020-06417-w
PMID: 32591966
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides and play important roles in a variety of diseases. LncRNAs are involved in many biologic processes including cell differentiation, development, and apoptosis. The intestinal barrier is considered one of the most important protective barriers in humans. Severe damage or dysfunction of the intestinal barrier may be associated with the occurrence and development of many diseases, such as inflammatory bowel disease and ulcerative colitis. LncRNAs have been found to be associated with intestinal barrier function in some studies, which are at an early stage. In this review, we introduce the roles of LncRNAs in the intestinal barrier and investigate the possibility of lncRNAs as a research field in the intestinal barrier.

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