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LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence

Authors
  • Lu, Jiaping1
  • Zhang, Naizheng2
  • Wu, Chen3
  • 1 Shanghai Xuhui Dental Hospital, No.3, Lane 244, Pingjiang Road, Xuhui District, Shanghai, 200030, People’s Republic of China , Shanghai (China)
  • 2 Shanghai Huangpu Dental Hospital, Shanghai, 200002, People’s Republic of China , Shanghai (China)
  • 3 Shanghai Baoshan Traditional Chinese Medicine-Integrated Hospital, Shanghai, 201900, People’s Republic of China , Shanghai (China)
Type
Published Article
Journal
BMC Oral Health
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 14, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12903-019-0993-0
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundRecurrent aphthous stomatitis (RAS) is a common oral disease with unknown molecular pathogenesis. Our preliminary microarray analysis revealed the altered expression of lncRNA Cancer Susceptibility Gene 2 (CASC2) in RAS. We therefore analyzed the role of CASC2 in RAS.MethodsIn this study, plasma samples were obtained from RAS patients and healthy participants. Plasma levels of CASC2 were measured by RT-qPCR. Plasma levels of IL-6 and IL-18 were measured by enzyme-linked immunosorbent assay (ELISA). A follow-up study was performed to analyze the role of CASC2 in the recurrence of RAS.ResultsIn the present study, we found that lncRNA Cancer Susceptibility Gene 2 (CASC2), as well as pro-inflammatory factors interleukin 6 (IL-6) and interleukin 18 (IL-18), were upregulated in plasma of RAS patients compared with healthy participants. Plasma levels of lncRNA CASC2 were positively correlated with plasma levels of IL-6 and IL-18 in RAS patients but not in healthy participants. Compared with pre-treatment levels, plasma levels of lncRNA CASC2, IL-6 and IL-18 were reduced after recovery. A follow-up study showed that patients with high levels of lncRNA CASC2 had a significantly higher recurrence rate.ConclusionLncRNA CASC 2 is upregulated in RAS and predicts the recurrence.

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