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Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

Authors
  • Edmunds, Lia R.1
  • Xie, Bingxian1
  • Mills, Amanda M.1
  • Huckestein, Brydie R.1
  • Undamatla, Ramya1
  • Murali, Anjana1
  • Pangburn, Martha M.1
  • Martin, James2, 3
  • Sipula, Ian1
  • Kaufman, Brett A.2, 3
  • Scott, Iain2, 3
  • Jurczak, Michael J.1, 3
  • 1 Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  • 2 Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  • 3 Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jul 10, 2020
Volume
41
Identifiers
DOI: 10.1016/j.molmet.2020.101051
PMID: 32653576
PMCID: PMC7399260
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Mitochondrial respiratory capacity is reduced in liver-specific Prkn knockout mice. • Liver-specific Prkn knockout mice develop more severe steatosis during high-fat diet feeding. • Pathogenesis of NAFLD, including insulin resistance and markers of fibrosis, is enhanced in liver-specific Prkn knockout mice.

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