Affordable Access

deepdyve-link
Publisher Website

Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis.

Authors
  • Marengo, Andrea1
  • Rosso, Chiara1
  • Bugianesi, Elisabetta1
Type
Published Article
Journal
Annual Review of Medicine
Publisher
Annual Reviews
Publication Date
Jan 01, 2016
Volume
67
Pages
103–117
Identifiers
DOI: 10.1146/annurev-med-090514-013832
PMID: 26473416
Source
Medline
Keywords
License
Unknown

Abstract

The burden of hepatocellular carcinoma (HCC), the most common form of liver cancer, is steadily growing because obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD) are replacing viral- and alcohol-related liver disease as major pathogenic promoters. The most worrisome aspects of these new risk factors are their large spread in the general population and their link with HCC arising in noncirrhotic livers. HCC may be the presenting feature of an asymptomatic nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD. The HCC risk connected to metabolic factors has been underestimated so far, and a poorer surveillance has prevented an adequate treatment. Systemic and hepatic molecular mechanisms involved in obesity- and NAFLD-induced hepatocarcinogenesis as well as potential early markers of HCC are being extensively investigated. This review summarizes current evidence linking obesity, NAFLD and liver cancer, discusses its clinical impact and describes the main mechanisms underlying this complex relationship.

Report this publication

Statistics

Seen <100 times