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Liver and brain thiamin depletion and neurologic signs in pigeon athiaminosis.

Authors
  • Ferrari, G
  • Cappelli, V
  • Cariani, T
Type
Published Article
Journal
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Publication Date
Jan 01, 1976
Volume
46
Issue
3
Pages
303–309
Identifiers
PMID: 977216
Source
Medline
License
Unknown

Abstract

Blood pyruvate and free and phosphorylated thiamin contents of liver and brain were measured in pigeons during diatary thiamin deficiency. Neurologic signs (opisthotonus and ataxia) appeared in the course of thiamin deficiency or did not appear at all during the entire athiaminosis period. As compared to respective controls, which never exhibited any neurologic abnormalities in spite of thiamin deficiency, the symptomatic animals had a higher pyruvate level in blood and a significantly lower phosphorylated thiamin content in both liver and brain. A hypothesis on relationship between phosphorylated thiamin content of liver and brain and occurence of nervous symptoms was expressed.

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