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[Live cold-adapted influenza vaccine: state-of-the-art].

Authors
  • Gendon, Iu Z
Type
Published Article
Journal
Voprosy virusologii
Publication Date
Jan 01, 2011
Volume
56
Issue
1
Pages
4–17
Identifiers
PMID: 21427948
Source
Medline
License
Unknown

Abstract

The review characterizes the currently used cold-adapted donor strains of influenza virus attenuation to prepare cold-adapted reassortants with actual epidemic influenza virus strains. It considers new procedures for preparing attenuated influenza virus strains for live influenza vaccines, as well as analytical methods and the genome composition of reassortants. Recent data on the safety of live cold-adapted influenza vaccines (LCAIVs), including those on the genetic stability of vaccine reassortants and the immunogenicity and efficacy of these vaccines for different age groups, are discussed. There is evidence for the design of live human vaccines against avian influenza. It is concluded that LCAIVs are highly effective for immunization of children.

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