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Live attenuated Salmonella vaccines and their potential as oral combined vaccines carrying heterologous antigens.

Authors
Type
Published Article
Journal
Journal of Immunological Methods
0022-1759
Publisher
Elsevier
Publication Date
Volume
142
Issue
1
Pages
113–120
Identifiers
PMID: 1919015
Source
Medline

Abstract

Live attenuated salmonellae are protective, and are candidate vaccines against invasive salmonella infections in man and animals. Different attenuating mutations have been described, and more than one can be incorporated in a vaccine for added safety. Combined salmonella vaccines express target carbohydrate and protein antigens or epitopes from viruses, bacteria and eukaryotic parasites, either within or on the surface of the cell, as capsules, fimbriae, or in the flagellin. Humoral, secretory and cellular responses to the recombinant antigens has been demonstrated. Experimental protection against diseases including streptococcal infection, tetanus, influenza and malaria has been obtained.

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