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A literature review of flavonoids and lifespan in model organisms.

Authors
  • Pallauf, Kathrin1
  • Duckstein, Nils1
  • Rimbach, Gerald1
  • 1 Institute of Human Nutrition and Food Science, University of Kiel,Germany. , (Germany)
Type
Published Article
Journal
Proceedings of The Nutrition Society
Publisher
Cambridge University Press
Publication Date
May 2017
Volume
76
Issue
2
Pages
145–162
Identifiers
DOI: 10.1017/S0029665116000720
PMID: 27609098
Source
Medline
Keywords
License
Unknown

Abstract

Epidemiological data on consumption of flavonoid-containing food points to the notion that some of these secondary plant metabolites may favour healthy ageing. The aim of the present paper was to review the literature on lifespan extension by flavonoids in worms, flies and mice. In most studies, worms and flies experienced lifespan extension when supplemented with flavonoids either as extracts or single compounds. Studies with mutant worms and flies give hints as to which gene products may be regulated by flavonoids and consequently enhance longevity. We discuss the data considering putative mechanisms that may underlie flavonoid action such as energy-restriction-like effects, inhibition of insulin-like-growth-factor signalling, induction of antioxidant defence mechanisms, hormesis as well as antimicrobial properties. However, it remains uncertain whether human lifespan could be prolonged by increased flavonoid intake.

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