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Listeria monocytogenes - from saprophyte to intracellular pathogen.

Authors
  • Freitag, Nancy E
  • Port, Gary C
  • Miner, Maurine D
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Sep 01, 2009
Volume
7
Issue
9
Pages
623–628
Identifiers
DOI: 10.1038/nrmicro2171
PMID: 19648949
Source
Medline
License
Unknown

Abstract

Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we describe the regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage.

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