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Liposomal α-galactosylceramide is taken up by gut-associated lymphoid tissue and stimulates local and systemic immune responses.

Authors
  • Kaneko, Kan1
  • McDowell, Arlene1
  • Ishii, Yasuyuki2
  • Hook, Sarah1
  • 1 School of Pharmacy, University of Otago, Dunedin, New Zealand. , (New Zealand)
  • 2 Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Japan. , (Japan)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Dec 01, 2017
Volume
69
Issue
12
Pages
1724–1735
Identifiers
DOI: 10.1111/jphp.12814
PMID: 28872688
Source
Medline
Keywords
License
Unknown

Abstract

These results show that oral delivery of a liposomal α-GalCer can stimulate local and systemic immune responses to a different degree compared to the non-liposomal form.

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