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Lipopolysaccharide interferes with the induction of peripheral T cell death.

Authors
  • Vella, A T
  • McCormack, J E
  • Linsley, P S
  • Kappler, J W
  • Marrack, P
Type
Published Article
Journal
Immunity
Publisher
Elsevier
Publication Date
Mar 01, 1995
Volume
2
Issue
3
Pages
261–270
Identifiers
PMID: 7535182
Source
Medline
License
Unknown

Abstract

In mice injected with superantigens, T cells specific for that antigen proliferate and then die. It has been suggested that the target cells die because they encounter superantigen on the surfaces of nonprofessional presenting cells, such as B cells, which cannot deliver costimulatory signals to T cells. A number of reagents that induce costimulatory molecules on B cells were tested. Lipopolysaccharide very effectively prevented T cell death driven by superantigen. Perhaps surprisingly, the action of lipopolysaccharide was not mediated through the expected costimulatory molecule, B7. Rather, the effects of lipopolysaccharide involved the production of inflammatory cytokines, in particular TNF alpha. The rescued cells survived in vitro culture and were resistant to Fas-induced killing. These data demonstrate that LPS can block antigen-induced T cell death perhaps by interfering with Fas signaling.

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