Affordable Access

deepdyve-link
Publisher Website

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders.

Authors
  • Yu, Qianhui1, 2
  • He, Zhisong2, 3
  • Zubkov, Dmitry3
  • Huang, Shuyun2, 4
  • Kurochkin, Ilia3
  • Yang, Xiaode1, 2
  • Halene, Tobias5
  • Willmitzer, Lothar6
  • Giavalisco, Patrick7
  • Akbarian, Schahram8
  • Khaitovich, Philipp9, 10, 11, 12
  • 1 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. , (China)
  • 2 CAS Key Laboratory of Compstudy has been deposited in the National Omics Datautational Biology, CAS-MPG Partner Institute for Computational Biology, SIBS, CAS, Shanghai, 200031, China. , (China)
  • 3 Skolkovo Institute of Science and Technology, Moscow, 143028, Russia.
  • 4 ShanghaiTech University, Shanghai, 200031, China. , (China)
  • 5 Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • 6 Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Potsdam, 14476, Germany. , (Germany)
  • 7 Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Potsdam, 14476, Germany. [email protected] , (Germany)
  • 8 Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [email protected]
  • 9 Skolkovo Institute of Science and Technology, Moscow, 143028, Russia. [email protected]
  • 10 ShanghaiTech University, Shanghai, 200031, China. [email protected] , (China)
  • 11 Max Planck Institute for Evolutionary Anthropology, Leipzig, 04103, Germany. [email protected] , (Germany)
  • 12 Comparative Biology Group, CAS-MPG Partner Institute for Computational Biology, SIBS, CAS, Shanghai, 200031, China. [email protected] , (China)
Type
Published Article
Journal
Molecular psychiatry
Publication Date
Nov 01, 2020
Volume
25
Issue
11
Pages
2952–2969
Identifiers
DOI: 10.1038/s41380-018-0200-8
PMID: 30089790
Source
Medline
Language
English
License
Unknown

Abstract

Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down syndrome (DS). Of the 5024 detected lipids, 95% showed significant age-dependent concentration differences clustering into four temporal stages, and resulting in a gradual increase in membrane fluidity in individuals ranging from newborn to nonagenarian. Aging affects 14% of the brain lipidome with late-life changes starting predominantly at 50-55 years of age-a period of general metabolic transition. All three diseases alter the brain lipidome composition, leading-among other things-to a concentration decrease in glycerophospholipid metabolism and endocannabinoid signaling pathways. Lipid concentration decreases in SZ were further linked to genetic variants associated with disease, indicating the relevance of the lipidome changes to disease progression.

Report this publication

Statistics

Seen <100 times