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Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages.

Authors
  • Auriac, Anne
  • Willemetz, Alexandra
  • Canonne-Hergaux, François
Type
Published Article
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Publication Date
Aug 01, 2010
Volume
95
Issue
8
Pages
1269–1277
Identifiers
DOI: 10.3324/haematol.2009.019992
PMID: 20220061
Source
Medline
License
Unknown

Abstract

Macrophage ferroportin is present in lipid rafts which contribute to hepcidin activity. These observations reveal the existence of a new cellular pathway in hepcidin mediated degradation of ferroportin and open a new area of investigation in mammalian iron homeostasis.

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