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Linkage of TNF genes to the HLA-B locus.

Authors
  • H Inoko
  • J Trowsdale
Publication Date
Nov 11, 1987
Source
PMC
Disciplines
  • Medicine
License
Unknown

Abstract

Pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) alpha and beta genes. They were shown to be linked to the HLA-B locus; analogous to their location in mouse, between the complement (class III) region and H-2D. However, the distance between the TNF genes and the class I region was much greater in man, namely about 260 kb, compared to 70 kb in the mouse. This finding may have implications for some HLA associated diseases.

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