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The Link between Stress and IL-6 Is Heating Up.

Authors
  • Darcy, Justin1
  • Tseng, Yu-Hua2
  • 1 Joslin Diabetes Center, Section on Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA.
  • 2 Joslin Diabetes Center, Section on Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: [email protected]
Type
Published Article
Journal
Cell metabolism
Publication Date
Aug 04, 2020
Volume
32
Issue
2
Pages
152–153
Identifiers
DOI: 10.1016/j.cmet.2020.07.011
PMID: 32755607
Source
Medline
Language
English
License
Unknown

Abstract

Psychological stress has long been known to reduce adaptability to inflammatory challenges, although the precise mechanism has remained elusive. In a recent issue of Cell, Qing et al. (2020) demonstrate that psychological stress induces secretion of IL-6 from brown adipose tissue, which promotes hepatic gluconeogenesis, and reduces host fitness to inflammatory insults. Copyright © 2020 Elsevier Inc. All rights reserved.

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