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Is there a link between plasma progesterone 1-2 days before frozen embryo transfers (FET) and ART outcomes in frozen blastocyst transfers?

Authors
  • Ramos, Natalia N1
  • Pirtea, Paul1
  • Benammar, Achraf1
  • Ziegler, Dominique de1
  • Jolly, Emilie2
  • Frydman, Rene1
  • Poulain, Marine1, 3
  • Ayoubi, Jean Marc1, 3
  • 1 Department of Gynecology, Obstetrics and Reproductive Medicine, Foch Hospital, Suresnes, France. , (France)
  • 2 Clinical Biology Laboratory, Foch Hospital, Suresnes, France. , (France)
  • 3 University Paris-Saclay, INRAE, ENVA, UVSQ, BREED, Jouy-en-Josas, France. , (France)
Type
Published Article
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Publication Date
Jul 01, 2021
Volume
37
Issue
7
Pages
614–617
Identifiers
DOI: 10.1080/09513590.2020.1825669
PMID: 32996332
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To study the efficacy of combined administration of subcutaneous and vaginal progesterone for priming frozen blastocysts transfers, looking at progesterone levels and ART outcome. Retrospective study. Three hundred and twenty frozen blastocyst transfer cycles conducted in 213 women aged up to 42 years, BMI between 18 and 30 kg/m2, with anatomically normal uterus who underwent frozen embryo transfers (FETs) from February 2019 to December 2019 with a combined luteal-phase support (LPS) associating subcutaneous and vaginal progesterone. Patients with recurrent pregnancy loss (RPL) were excluded. When using combined vaginal and subcutaneous LPS, SPL >10.50 ng/mL in 95% of cases, with a minimum value of 7.02 ng/mL. CPR, OPR, and global miscarriage rates were 38.4%, 30.9%, and 19.5%, respectively. Analyzing results per quartiles, revealed that miscarriage rates were significantly inferior, and IR were higher in the upper two quartiles of serum progesterone (>21.95 ng/mL) on the day before FET, while there was no difference in CPR and OPR. We report ART outcome of frozen blastocyst transfers performed using a combination of vaginal and subcutaneous progesterone for LPS. ART results were honorable and SPL favorable 1-2 days before FET in 99% of cases.

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