Affordable Access

deepdyve-link
Publisher Website

Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis.

Authors
  • Yuan, Joan
  • Nguyen, Cuong K
  • Liu, Xiuhuai
  • Kanellopoulou, Chrysi
  • Muljo, Stefan A
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Mar 09, 2012
Volume
335
Issue
6073
Pages
1195–1200
Identifiers
DOI: 10.1126/science.1216557
PMID: 22345399
Source
Medline
License
Unknown

Abstract

The immune system develops in waves during ontogeny; it is initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We report that Lin28b is specifically expressed in mouse and human fetal liver and thymus, but not in adult bone marrow or thymus. We demonstrate that ectopic expression of Lin28 reprograms hematopoietic stem/progenitor cells (HSPCs) from adult bone marrow, which endows them with the ability to mediate multilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a, marginal zone B, gamma/delta (γδ) T cells, and natural killer T (NKT) cells.

Report this publication

Statistics

Seen <100 times