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Limb salvage with major nerve injury: current management and future directions.

Authors
  • Kang, Jason R
  • Zamorano, David P
  • Gupta, Ranjan
Type
Published Article
Journal
Journal of the American Academy of Orthopaedic Surgeons
Publisher
American Academy of Orthopaedic Surgeons
Publication Date
Jan 01, 2011
Volume
19 Suppl 1
Identifiers
PMID: 21304044
Source
Medline
License
Unknown

Abstract

Major peripheral nerve injuries are often associated with devastating functional deficits. Current management techniques fail to achieve adequate functional neural regeneration, and the development of adjunct therapies is necessary to improve outcomes. Recent efforts at enhancing the regeneration rate of peripheral nerves and developing axonal guidance channels or conduits have had limited success. The neuromuscular junction serves as the interface between the peripheral nerves and muscle. This critical area undergoes significant changes following peripheral nerve injury and induces end-organ atrophy after denervation, which limits the chance of true functional regeneration. Stabilization of the neuromuscular junction may be an important adjunct in peripheral nerve repair and should be explored as a method of managing major nerve injuries.

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