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Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

Authors
  • Zhang, Bingqian1, 2, 3, 1
  • Zhou, Wei1, 2, 3, 1
  • Shi, Yuhua1, 2, 3, 1
  • Zhang, Jun4
  • Cui, Linlin1, 2, 3, 1
  • Chen, Zi-Jiang1, 2, 3, 1, 5, 6
  • 1 Shandong University, No.157 of Jingliu Street, Jinan, Shandong, 250012, China , Jinan (China)
  • 2 Shandong University, No.44 of Wenhua Street, Jinan, Shandong, 250012, China , Jinan (China)
  • 3 Shandong University, No.44 of Wenhua street, Jinan, Shandong, 250012, China , Jinan (China)
  • 4 Shanghai Jiao-Tong University, No.1665 of Kongjiang Street, Shanghai, 200092, China , Shanghai (China)
  • 5 Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, No.845 of Lingshan Street, Shanghai, 200088, China , Shanghai (China)
  • 6 Shanghai Jiao Tong University, No.845 of Lingshan Street, Shanghai, 200088, China , Shanghai (China)
Type
Published Article
Journal
BMC Endocrine Disorders
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 30, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12902-020-0497-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundPolycystic ovary syndrome (PCOS) is the most common reason of anovulatory infertility. Environmental factor is one of the main causes of PCOS, but its contribution to ovulatory dysfunction in PCOS remains unknown.MethodsA total of 2217 infertile women diagnosed as PCOS according to Rotterdam criteria were recruited, including 1979 women with oligo-anovulation (OA group) and 238 women with normal -anovulation (non OA group). Besides, 279 healthy control women of reproductive age were enrolled as controls.ResultsFrequencies of snoring (PCOS-OA group, PCOS-non-OA group, control group: 29.30% vs 18.10% vs 11.50%, P < 0.01), smoking (37.70% vs 28.10% vs 12.20%, P < 0.01), plastic tableware usage (38.30% vs 28.10% vs 25.40%, P < 0.01) and indoor decoration (32.10% vs 24.80% vs 16.80%, P < 0.01) were highest in PCOS-OA group. After adjusted for multivariable, difference remained significant between PCOS-OA group and the other two groups. PCOS-OA women preferred a meat favorable diet compared to PCOS-non-OA group (54.60% vs 41.30%, P < 0.01). There was no difference between three groups in exercise, frequency of insomnia, and alcohol consumption.ConclusionsSmoking, snoring, hyper-caloric diet, plastic tableware usage and indoor decoration were found to be associated with an increased risk for ovulatory dysfunction in women suffering from PCOS.

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