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Lewis Acid Mediated Cascade Friedel-Craft/Alkyne Indo1-2-y1 Cation Cyclization/Vinyl Cation Trapping for the Synthesis of N-Fused Indole Derivatives

Authors
  • GHARPURE, SJ
  • SHELKE, YG
Publication Date
Nov 28, 2017
Source
DSpace at IIT Bombay
Keywords
License
Unknown
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Abstract

A Lewis acid promoted cascade Friedel-Craft/alkyne indol-2-yl cation cyclization/vinyl cation trapping for an efficient and divergent synthesis of N-fused indoles is developed. The present study illustrates the first example of an alkyne as a nudeophile on the less explored indo1-2-y1 cation. The method efficiently affords pharmaceutically important pyrrolizino-quinolines and complex fused indole derivatives in high yields.

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