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Levothyroxine replacement dose for primary hypothyroidism decreases with age.

Authors
  • Rosenbaum, R L
  • Barzel, U S
Type
Published Article
Journal
Annals of Internal Medicine
Publisher
American College of Physicians
Publication Date
Jan 01, 1982
Volume
96
Issue
1
Pages
53–55
Identifiers
PMID: 7053703
Source
Medline
License
Unknown

Abstract

We studied 23 elderly (other than 65) and 44 younger ambulatory adult patients with primary hypothyroidism to ascertain the dose of levothyroxine needed for complete replacement in relation to age. The elderly patients (average age, 75.7 years) needed an average 118 microgram/d whereas the younger patients (average age, 48.1 years) needed 158 microgram/d. The data indicate that thyroxine requirement may decrease continuously with age. This decrease probably reflects the progressive decrease in thyroxine degradation rate that occurs with age.

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