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Levels of vancomycin in cerebrospinal fluid of adult patients receiving adjunctive corticosteroids to treat pneumococcal meningitis: a prospective multicenter observational study.

Authors
  • 1
Type
Published Article
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1537-6591
Publication Date
Volume
44
Issue
2
Pages
250–255
Identifiers
PMID: 17173226
Source
Medline

Abstract

Appropriate concentrations of vancomycin in CSF may be obtained even when concomitant steroids are used. Dexamethasone can, therefore, be used without fear of impeding vancomycin penetration into the CSF of patients with pneumococcal meningitis, provided that vancomycin dosage is adequate. This study is registered at http://www.ClinicalTrials.gov/ (registration number NCT00162578).

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