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Level of Sensibilization of Immunocompetent Cells as a Criterion of Efficacy of Introduction of Cryopreserved Fetal Nerve Cells in Experimental Allergic Encephalomyelitis

Authors
  • Porozhan, E. A.1
  • Gol’tsev, A. N.1
  • Babenko, N. N.1
  • Dubrava, T. G.1
  • 1 National Academy of Sciences of Ukraine, Institute of Problems of Cryobiology and Cryomedicine, Khar’kov, Ukraine , Khar’kov (Ukraine)
Type
Published Article
Journal
Neurophysiology
Publisher
Birkhäuser-Verlag
Publication Date
Sep 01, 2012
Volume
44
Issue
4
Pages
292–300
Identifiers
DOI: 10.1007/s11062-012-9299-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

We obtained data that substantiate the possibility of using the level of sensibilization of immunocompetent cells as an assessment criterion of the severity of experimental allergic encephalomyelitis (EAE), as well as to determine the therapeutic efficacy of using cryopreserved fetal nerve cells (cFNCs) for treatment of this pathology. We demonstrated the dependence of a drop in the autoreactivity of lymphocytes in rats with EAE on the type of injected cellular material cryopreserved in different regimes. We discuss possible mechanisms underlying realization of the therapeutic effect of cFNAs.

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