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Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury.

Authors
  • Stanojcic, Mile
  • Chen, Peter
  • Harrison, Rachael A
  • Wang, Vivian
  • Antonyshyn, Jeremy
  • Zúñiga-Pflücker, Juan Carlos
  • Jeschke, Marc G
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 01, 2014
Volume
42
Issue
6
Pages
1357–1364
Identifiers
DOI: 10.1097/CCM.0000000000000209
PMID: 24584061
Source
Medline
License
Unknown

Abstract

In summary, our study is the first to show activation of the inflammasome in burned humans, and our results provide impetus for further investigation of the role of the inflammasome in burn-induced hypermetabolism and, potentially, developing novel therapies targeting this protein complex for the treatment of stress-induced diabetes.

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