Pragmatic studies are common in nursing research. These studies range from secondary analysis of large observational datasets to prospective randomized multisite clinical trials. The common elements in pragmatic studies are the real-world settings in which the research occurs: settings that decrease threats to external validity, but may increase threats to internal validity of the research. This manuscript presents a pragmatic study and the methodological considerations in design and analytic approaches that were undertaken to decrease all threats to validity while maintaining study feasibility. A pragmatic study design and analytic choices are presented and evaluated. To increase robustness of the study and internal and external validity of findings, while maintaining feasibility, unique approaches to design and analyses were chosen. Like efficacy studies, pragmatic studies are essential to nursing research and require additional a priori considerations in design and analyses to increase internal validity of findings. Copyright © 2018 Elsevier Inc. All rights reserved.