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Lesion measurement on a combined “all-in-one” window for chest CT: effect on intra- and interobserver variability

Authors
  • Snoeckx, Annemiek1
  • Cant, Jeroen2
  • Franck, Caro1
  • Luyckx, Elisa1
  • Carpentier, Ken1
  • Nicolay, Simon1
  • Van Hoyweghen, Astrid1
  • Spinhoven, Maarten J.1
  • Vuylsteke, Pieter2
  • Parizel, Paul M.1
  • 1 Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, Edegem, 2650, Belgium , Edegem (Belgium)
  • 2 Agfa Medical Imaging, Septestraat 27, Mortsel, 2640, Belgium , Mortsel (Belgium)
Type
Published Article
Journal
Cancer Imaging
Publisher
BioMed Central
Publication Date
Nov 29, 2019
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s40644-019-0262-0
Source
Springer Nature
Keywords
License
Green

Abstract

PurposeA newly developed image processing technique fuses conventional windows into a single ‘All-In-One’ (AIO) window. This study aims to evaluate variability of CT measurement of lesions in thoracic oncology patients on this novel AIO-window.MethodsSix radiologists with different levels of expertise measured 368 lesions of various size, origin and sharpness. All lesions were measured twice on the AIO-window and twice on the conventional window settings. Intraclass correlation coefficients and Bland-Altman plots were used to assess intra- and interobserver variability.ResultsOverall intra-observer agreement for lesion diameters on the AIO-window and conventional window settings was 0.986 (95% Confidence interval (CI): 0.983–0.989) and 0.991 (95% CI 0.989–0.993) respectively. For interobserver agreement this was 0.982 (95% CI 0.979–0.985) (AIO) and 0.979 (95% CI 0.957–0.982) (conventional). For both the AIO and conventional windows, intra- and interobserver agreement were dependent on size, sharpness and reader experience. Measurement variability decreased with increasing lesion size. Regarding sharpness, inter- and intra-observer agreement ranged from 0.986–0.989 (AIO) and 0.985–0.992 (conventional) for well-defined lesions and from 0.978–0.983 (AIO) and 0.974–0.991 (conventional) for ill-defined lesions.ConclusionsLesion diameters were consistently smaller on the AIO-window compared to conventional window settings. Overall intra- and interobserver variability rates were similar for the AIO-window and conventional window settings. We conclude that the AIO-window offers a reliable and reproducible alternative for measurement of thoracic lesions.

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