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Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells.

Authors
  • Brown, James E P
  • Dunmore, Simon J
Type
Published Article
Journal
Diabetes/metabolism research and reviews
Publication Date
Sep 01, 2007
Volume
23
Issue
6
Pages
497–502
Identifiers
PMID: 17318810
Source
Medline
License
Unknown

Abstract

We conclude that leptin reduces apoptosis in beta-cells at physiological concentrations, possibly via its ability to up-regulate BCL-2 and Bax expression.

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