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LEP gene allelic polymorphism in a subpopulation of Ayrshire cattle

Authors
  • Kovaljuk, N. V.1
  • Satsuk, V. F.2
  • Volchenko, A. E.1
  • Machulskaja, E. V.1
  • 1 North-Caucasus Scientific Research Institute of Animal Industries of the Russian Academy of Agricultural Sciences, Krasnodar, 350055, Russia , Krasnodar (Russia)
  • 2 Aster, Limited, a Scientific Production Agricultural Enterprise, Krasnodar, 350055, Russia , Krasnodar (Russia)
Type
Published Article
Journal
Russian Journal of Genetics
Publisher
Pleiades Publishing
Publication Date
Feb 01, 2015
Volume
51
Issue
2
Pages
214–217
Identifiers
DOI: 10.1134/S1022795415020106
Source
Springer Nature
Keywords
License
Yellow

Abstract

Genotyping of the leptin gene locus (LEP) (SNP: R25C, Y7F, and A80V) has been conducted in cows from two cattle droves (n = 106 and n = 34) and in bulls of Ayrshire cattle (n = 9) that are intensively used at present for artificial insemination in cows in Krasnodar krai. The absence of A80V polymorphism (C→T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle; however, the F allele (Y7F site A→T at position 95689996 bp of LEP gene), which is rare in Holstein cattle, was shown to be frequent in Ayrshire cows and producer bulls (with a frequency of 0.22–0.79). The heterozygosity did not exceed 0.11 in adult animals, which might be evidence of a decreased vitality in animals bearing the FF genotype. Moreover, the CC genotype (R25C site T→C at position 95690050 bp of LEP gene) was revealed to be linked to the YY genotype (Y7F site) in 97% of cases from possible combinations of the CCYY, CCYF, and CCFF genotypes, while the FF genotype (Y7F site) was observed to be linked to the RR genotype (R25C site) in 100% of cases of possible combinations of FFCC, FFRC, and FFRR genotypes.

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