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Lens cataract formation and reversible alteration in crystallin synthesis in cultured lenses.

Authors
  • Piatigorsky, J
  • Shinohara, T
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jun 17, 1977
Volume
196
Issue
4296
Pages
1345–1347
Identifiers
PMID: 559349
Source
Medline
License
Unknown

Abstract

Embryonic chick lenses developed cortical cataracts and altered their pattern of delta-crystallin synthesis within 3 hours, if cultured without their vitreous body or traumatized with their vitreous body attached. delta-Crystallin reverted to the normal pattern by 24 hours in the cataractous lenses. Thus, biochemical differences that are only observable during the initial stages of cataractogenesis can exist between opaque and normal lenses.

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