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Leishmania braziliensis panamensis: increased infectivity resulting from heat shock.

Authors
Type
Published Article
Journal
Experimental parasitology
Publication Date
Volume
65
Issue
1
Pages
1–9
Identifiers
PMID: 3338542
Source
Medline
License
Unknown

Abstract

Promastigotes of Leishmania braziliensis panamensis were subjected to a heat shock transformation yielding an amastigote-like stage. During the process of conversion, the heat-induced differentiating form displayed an increase in infectivity (as determined by lesion size) accompanied by a total protein composition unlike that of the promastigote and a morphology resembling that of the amastigote. These biological/functional changes may be related to an involvement of a heat shock response in the differentiation of leishmania, thus having important implications in the development of prevention and treatment stratagems.

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