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Leiomyosarcoma arising in irradiated region after breast-conserving surgery: a case report

Authors
  • Hayashi, Satoshi1
  • Kitada, Masahiro1
  • Matsuda, Yoshinari1
  • Ishibashi, Kei1
  • Takahashi, Nana1
  • 1 Asahikawa Medical University, Breast Center, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan , Asahikawa (Japan)
Type
Published Article
Journal
Surgical Case Reports
Publisher
Springer Berlin Heidelberg
Publication Date
Sep 07, 2015
Volume
1
Issue
1
Identifiers
DOI: 10.1186/s40792-015-0072-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundRadiation therapy (RT) is considered a risk factor for the development of sarcoma in patients with breast cancer. However, there are few reports regarding post-irradiation sarcoma (PIS).Case presentationThe patient was a 59-year-old woman who presented with a chief complaint of induration in the lower outer quadrant of the left breast. She underwent breast-conserving surgery (BCS) for breast cancer located in the left upper inner region and received endocrine therapy following RT (50 Gy/25 fractions/5 weeks) for breast conservation 6 years previously. Core needle biopsy revealed leiomyosarcoma. There was no distant metastasis. Repeat BCS including part of the pectoralis major muscle was performed. Chest wall resection was not performed because of the lack of invasion. Based on the morphological and immunohistochemical features, a diagnosis of leiomyosarcoma was made. All of the resection margins in the specimen were tumor-free. She has been disease-free for over 20 months.ConclusionsPost-irradiation leiomyosarcoma is an extremely rare tumor with high malignant potential, and thus, multidisciplinary therapy and close follow-up are advised.

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