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Left ventricular geometry and risk of incident hypertension.

Authors
  • Park, Sung Keun1
  • Jung, Ju Young2
  • Kang, Jeong Gyu2
  • Chung, Pil-Wook3
  • Oh, Chang-Mo4
  • 1 Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 2 Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 3 Department of Neurology, College of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 4 Department of Preventive Medicine, School of Medicine, Kyung Hee University, Dongdaemun-gu, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Heart
Publisher
BMJ
Publication Date
Sep 01, 2019
Volume
105
Issue
18
Pages
1402–1407
Identifiers
DOI: 10.1136/heartjnl-2018-314657
PMID: 30995990
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Left ventricular (LV) geometry change is an independent predictor for cardiovascular disease. However, data are equivocal on the association of echocardiographic parameters of LV geometry with incident hypertension. Thus, we were to investigate the risk of hypertension according to the baseline echocardiographic parameters of LV geometry. Study participants were 12 562 Koreans without hypertension who received echocardiography as an item of health check-up. They were divided into normotensive or prehypertensive group according to baseline blood pressure. In each group, study subjects were classified by quintiles of baseline echocardiographic parameters including left ventricular mass index (LVMI), relative wall thickness (RWT), interventricular septal thickness (IVST), posterior wall thickness (PWT) and IVST plus PWT and followed up for 5 years. Cox proportional hazards model was used in calculating adjusted HRs and their 95% CI for hypertension according to each quintile group. Area under the curve (AUC) analysis (AUC [95% CI]) was performed to compare the predictability of LVMI, RWT, IVST, PWT, IVST plus PWT for hypertension. Prehypertensive group had the worse clinical and echocardiographic parameters in baseline analysis than normotensive group. The risk of hypertension significantly increased proportionally to baseline LVMI, RWT, IVST, PWI and IVST plus PWT above specific quintile levels, which was identified in both normotensive and prehypertensive group. In AUC analysis, IVST, PWT and IVST plus PWT showed a significantly increased AUC, compared with LVMI. LV geometry change was significantly associated with the increased risk for hypertension in non-hypertensive individuals. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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