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LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics

Authors
  • khan, imran
  • nam, miso
  • kwon, minji
  • seo, sang-soo
  • jung, sunhee
  • han, soo
  • hwang, geum-sook
  • kim, kyung
Publication Date
Apr 10, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

0.0001) and were associated with increased risk of developing CIN2/3 and cervical cancer. Additionally, elevated levels of the seven metabolites combined with positive HPV status were correlated with substantial risk of cancer progression. These results demonstrated that metabolomics profiling is capable of distinguishing CINs and cervical cancers from normal and highlighted potential biomarkers for the early detection of cervical carcinogenesis.

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