Affordable Access

deepdyve-link
Publisher Website

Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network.

Authors
  • Authimoolam, Sundar P1
  • Lakes, Andrew L1
  • Puleo, David A2
  • Dziubla, Thomas D3
  • 1 Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky, 40506, USA.
  • 2 Department of Biomedical Engineering, College of Engineering, University of Kentucky, 522 Robotics Building, Lexington, Kentucky, 40506, USA.
  • 3 Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky, 40506, USA. [email protected]
Type
Published Article
Journal
Macromolecular bioscience
Publication Date
February 2016
Volume
16
Issue
2
Pages
242–254
Identifiers
DOI: 10.1002/mabi.201500310
PMID: 26418812
Source
Medline
Keywords
License
Unknown

Abstract

Mucin networks are lubricous biofunctional coats formed through the continuous deposition of mucin glycoproteins. Previously, we demonstrated the synthesis of a mucin mimic using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer approach. These networks recreate the fibrous nature of mucin and can serve as a drug-releasing network. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition, the deposition of a dense polymer coating on the mucin network was shown to act as a barrier to control diffusion and improved the structural stability under simulated oral chemical conditions. These biomimetic coatings can be utilized as a delivery system, providing a tunable drug release for oral applications.

Report this publication

Statistics

Seen <100 times