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Latinas' knowledge of and experiences with genetic cancer risk assessment: Barriers and facilitators.

Authors
  • Gómez-Trillos, Sara1, 2
  • Sheppard, Vanessa B3
  • Graves, Kristi D1, 2
  • Song, Minna1
  • Anderson, Lyndsay4
  • Ostrove, Nancy5
  • Lopez, Katherine1
  • Campos, Claudia6
  • Gonzalez, Nathaly7
  • Hurtado-de-Mendoza, Alejandra1, 2
  • 1 Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
  • 2 The Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research, Washington, District of Columbia.
  • 3 Department of Health Behavior and Policy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
  • 4 Department of Nursing, California State University, Sacramento, California.
  • 5 EXPRE, LLC, Gaithersburg, Maryland.
  • 6 Nueva Vida DC Office, Alexandria, Virginia.
  • 7 Capital Breast Cancer Center, Washington, District of Columbia.
Type
Published Article
Journal
Journal of genetic counseling
Publication Date
Aug 01, 2020
Volume
29
Issue
4
Pages
505–517
Identifiers
DOI: 10.1002/jgc4.1201
PMID: 31883202
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Disparities in genetic cancer risk assessment (GCRA) uptake persist between Latinas and Non-Hispanic Whites. This study utilized a mental model approach to interview 20 Latinas (10 affected, 10 unaffected) at increased risk for hereditary breast and ovarian cancer (HBOC). Participants were asked about their knowledge and perceptions of GCRA, HBOC, risk, benefits, motivators, barriers, challenges, and experiences with GCRA. Using the Consensual Qualitative Analysis Framework, two authors independently coded the interviews and applied the final codes upon consensus. Additionally, interviews were coded to identify whether participants spontaneously brought up certain topics without a prompt. Findings identified multiple barriers and facilitators to GCRA uptake in this population, including patient level psychosocial/cultural factors (e.g., limited knowledge, worry about relatives' risk) and healthcare system factors (e.g., receiving no referrals). There were notable differences in awareness and knowledge between affected and unaffected women (e.g., genetic testing awareness), as well as knowledge gaps that were evident in both groups (e.g., age of diagnosis as a risk factor). To reduce disparities in GCRA uptake, interventions should address identified facilitators and barriers. Differences in knowledge and awareness between affected and unaffected women support the development of targeted interventions that address specific knowledge gaps. This study was registered in ClinicalTrials.gov (NCT03075540) by Alejandra Hurtado de Mendoza, Ph.D. © 2019 National Society of Genetic Counselors.

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