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Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date.

Authors
  • Shukla, Navika D1
  • Ho, Allen L1
  • Pendharkar, Arjun V1
  • Sussman, Eric S1
  • Halpern, Casey H1
  • 1 Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Type
Published Article
Journal
Neuropsychiatric Disease and Treatment
Publisher
Dove Medical Press
Publication Date
Jan 01, 2017
Volume
13
Pages
2469–2475
Identifiers
DOI: 10.2147/NDT.S139544
PMID: 29026310
Source
Medline
Keywords
License
Unknown

Abstract

Medically intractable epilepsy is associated with increased morbidity and mortality. For those with focal epilepsy and correlated electrophysiological or radiographic features, open surgical resection can achieve high rates of seizure control, but can be associated with neurologic deficits and cognitive effects. Recent innovations have allowed for more minimally invasive methods of surgical seizure control such as magnetic resonance-guided laser interstitial therapy (MRgLITT). MRgLITT achieves the goal of ablating seizure foci while preserving neuropsycho-logical function and offering real-time feedback and monitoring of tissue ablation. This review summarizes the utilization of MRgLITT for mesial temporal lobe epilepsy and other seizure disorders. Overall, the efficacy of MRgLITT is comparable to that of open surgery and offers a less invasive approach in patients with significantly less morbidity.

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