LARP7 family proteins have conserved function in telomerase assembly
- Authors
- Type
- Published Article
- Journal
- Nature Communications
- Publisher
- Springer Nature
- Publication Date
- Feb 08, 2018
- Volume
- 9
- Issue
- 1
- Identifiers
- DOI: 10.1038/s41467-017-02296-4
- Source
- Springer Nature
- License
- Green
Abstract
The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.