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LARP7 family proteins have conserved function in telomerase assembly

Authors
  • Collopy, Laura C.1
  • Ware, Tracy L.1, 2
  • Goncalves, Tomas1, 3
  • í Kongsstovu, Sunnvør1, 4
  • Yang, Qian1
  • Amelina, Hanna1
  • Pinder, Corinne1, 3
  • Alenazi, Ala1, 4
  • Moiseeva, Vera1
  • Pearson, Siân R.1
  • Armstrong, Christine A.1
  • Tomita, Kazunori1
  • 1 University College London, Chromosome Maintenance Group, UCL Cancer Institute, London, WC1E 6DD, UK , London (United Kingdom)
  • 2 Salem State University, Department of Biology, Salem, MA, 01970, USA , Salem (United States)
  • 3 University College London, Division of Biosciences, Faculty of Life Sciences, London, WC1E 6BT, UK , London (United Kingdom)
  • 4 Imperial College London, MSc Human Molecular Genetics, Faculty of Medicine, London, SW7 2AZ, UK , London (United Kingdom)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Feb 08, 2018
Volume
9
Issue
1
Identifiers
DOI: 10.1038/s41467-017-02296-4
Source
Springer Nature
License
Green

Abstract

The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.

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