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A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer.

Authors
  • Cybulski, C
  • Wokołorczyk, D
  • Huzarski, T
  • Byrski, T
  • Gronwald, J
  • Górski, B
  • Debniak, T
  • Masojć, B
  • Jakubowska, A
  • Gliniewicz, B
  • Sikorski, A
  • Stawicka, M
  • Godlewski, D
  • Kwias, Z
  • Antczak, A
  • Krajka, K
  • Lauer, W
  • Sosnowski, M
  • Sikorska-Radek, P
  • Bar, K
  • And 8 more
Type
Published Article
Journal
Journal of Medical Genetics
Publisher
BMJ
Publication Date
Nov 01, 2006
Volume
43
Issue
11
Pages
863–866
Identifiers
PMID: 17085682
Source
Medline
License
Unknown

Abstract

A large deletion of exons 9 and 10 of CHEK2 confers an increased risk of prostate cancer in Polish men. The del5395 founder deletion might be present in other Slavic populations, including Ukraine, Belarus, Russia, Baltic and Balkan countries. It will be of interest to see to what extent this deletion is responsible for the burden of prostate cancer in other populations.

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